Cardiac mucosa at the gastroesophageal junction: An Eastern perspective

Histopathological features of the gastroesophageal junction: an Eastern view.

The definition and features of the gastroesophageal junction (GEJ) and the histopathologic features of the cardiac mucosa remain controversial. Most reports originate from western countries, which have different prevalence of GEJ adenocarcinoma and gastroesophageal reflux disease (GERD) compared to eastern countries. Therefore, we investigated GEJ anatomic and histopathologic features by histol...

Neuroendocrine Cells in Barrett’s Mucosa and Adenocarcinomas of the Gastroesophageal Junction

Neuroendocrine (NE) cells are defined as argentaffin and argyrophil cells that produce peptides or amines. They belong to the diffuse neuroendocrine system (DNES) and were previously known as amino-precursor-uptake-decarboxylation (APUD) cells. The neuroendocrine system of the normal gastrointestinal tract might regulate proliferation and growth of epithelial and mesenchymal cells and probably ...

Dedifferentiated Liposarcoma of the Gastroesophageal Junction.

Liposarcoma is one of the most common sarcomas in adults, but very rarely presents as a primary in the upper gastrointestinal system. Herein, we present a 71-year-old male patient who underwent wedge excision biopsy twice and then fine needle aspiration and total gastrectomy for a recurrent gastroeosophageal junction mass. In microscopic sections, both well-differentiated and dedifferentiated c...

Gastroesophageal Junction Pathology: Diagnostic and Controversial Issues

Therapeutic approaches to gastroesophageal junction adenocarcinomas.

The following, from the 12th OESO World Conference: Cancers of the Esophagus, includes commentaries on the distinction between adenocarcinomas above, below, or within the gastroesophageal junction; combined modality therapy; tumor markers for use in personalized medicine; PET-CT and endoscopic biopsies in the evaluation of response to neoadjuvant chemoradiation therapy; a standardized grading s...